2/28/13

1.  So...did OJ do it?
2. Notes: Other applications of DNA fingerprinting and PCR
3. Results: LAB: The Crooked Cell Gel Electrophoresis Lab - Using gel electrophoresis to determine the genotypes of Ava's family

H.W. Finish the lab analysis questions: (do this directly on your answer sheet)
#1 = Accurate drawing of your gel results
#2 = Sickle Cell Anemia Geneotypes and Phenotypes for Ava’s Family Table
#3. Explain why the carriers genetic profile appeared the way it did.
#4. Using the lab results for Ava and Ava’s grandmother on her father’s side, determine Ava’s father’s genotype and phenotype for the sickle cell trait. Explain how you came to this conclusion.
#5. Identify and describe two other applications of gel electrophoresis.

2/27/13

1. LAB: The crooked cell- Using gel electrophoresis to determine the genotypes of Ava's family

H.W. Finish the Hypothesis for the lab by creating a pedigree and predicting the genotypes of Ava and her tested family members.  In addition, using the picture from page 2 of the background information (under "Step 3: DNA digestion"), draw a gel that predicts the banding patterns that you will observe during the lab.

AND Read about The blood and DNA Evidence in the O.J. Simpson Trial by visiting: http://www.bxscience.edu/publications/forensics/articles/dna/r-dna02.htm
After reading the article, answer the following questions.
1.  What are 3 pieces of evidence from the article that incriminated O.J. Simpson?
2.  What are the names of the 2 DNA analysis techniques used in the O.J. Simpson trial? (abbreviations and full names)
3.  What are 2 reasons mentioned in the article for O.J.'s acquittal?
4.  Do you think O.J. Simpson is guilty or innocent of these crimes?  Support your answer.  

2/26/13

1. W.U. (Verbal only) Restriction Enzyme Review
2. Notes: Gel Electrophoresis

H.W. Read The Crooked Cell Gel Electrophoresis Lab and then answer the pre-lab questions (#1-8 only, you will work on the hypothesis -#9 in class tomorrow) on the answer sheet that you picked up in class today

2/25/13

1. Biotechnology Notes:  Restriction Enzymes

H.W. DNA Scissors (worksheet and DNA strands that were passed out in class today)

2/22/13

1. Curing ALD using human gene therapy activity

• Make your own recombinant virus
• Read the article on ALD
• Answer questions on the back of your recombinant virus

H.W. Finish Recombinant Virus (absent?  Read the article and questions linked above and then on Monday pick up your virus, viral genome and good gene from Mrs. W.)
 AND FINISH:
DNA Fingerprinting Webquest  (due MONDAY)

2/21/13

1. Intro to biotechnology (absent?  pick up the handout from me tomorrow)
- What is biotechnology?
- What are some application of biotechnology?
- What are some ethical considerations?

H.W. DNA Fingerprinting Webquest  (due MONDAY)

2/20/13

1.  Turn in your Genetics Unit Packet
2.  GENETICS TEST

H.W. Relax : )   

2/19/13

1. W.U. Red Alert:  New blood tests promise better, cheaper diagnosis (Time Magazine article)
2. Genetics Review!

H.W. STUDY (Chapters 11.1-11.3 and 14.1-14.2): GENETICS EXAM IS TOMORROW
& Put together your Genetics Unit Packet (this is your first unit packet of the semester, make it a good one!)  (this packet includes the Genetics Study Guide)

2/15/13

1. W.U. Pedigrees
2. Review 14.2 Notes: Human Genetic Disorders

H.W. Genetics Study Guide (highly recommended that you work on this over the weekend......officially due Wednesday)
GENETICS TEST (11.1-11.-3, 14.1-14.2)- WEDNESDAY 2/20  

2/14/13

1. W.U. What are the color of my genes (a refresher of sex-linked inheritance with the Untamed Science Crew)
2. Notes: Finish 14.1 (Sex influenced traits and pedigrees)
3. Notes: 14.2: on your own:  Use the 14.2 Notes that you printed last night, your book and these 3 articles to complete this assignment.

H.W. Finish 14.2 Notes by using your book and these 3 articles  (the entire assignment is due tomorrow)

GENETICS TEST (11.1-11.-3, 14.1-14.2)- WEDNESDAY 2/20  (STUDY GUIDE WILL BE POSTED TOMORROW NIGHT)

2/13/13

1. W.U. Analyzing Data: Human Blood Types (Q's #1-4 on page 320)
2. A friend in need....a simulated blood typing LAB

H.W. Finish the entire answer sheet from today's lab (front and back) AND print (only) these 14.2 Notes

2/12/13

1. W.U.. What does Bat Boy want to know about blood? (1/2 sheet of paper that was passed out in class)
2. Review H.W. and blood typing
3. Blood Typing Game

H.W. Open and read: A friend in need… Simulated Blood Typing Lab.  After reading the background information answer the 5 pre-lab questions that follow the reading.  These questions must be written on a separate sheet of paper and be in complete sentences.

2/8/13

1. Review H.W.
2. Notes: 14.1 Blood Typing

H.W. Blood Typing Tutorial Practice (due on Tuesday)

2/7/13

1. Review H.W.
2. Notes: 14.1- Human Chromosomes (a quick review)
3. REEBOP Lab- Final day

H.W. Read, summarize and hypothesize the Chapter 14 Chapter Mystery (do this directly in your notes) AND complete this 11.3 Patterns of Inheritance Review W.S. (this was passed out in class today)

2/6/13

1. Review H.W.
2. REEBOP LAB- day 2

H.W. Print 14.1 Notes and do these:

EVEN MORE PATTERNS OF INHERITANCE PRACTICE PROBLEMS (Sex Linked Inheritance Practice Problems)

Answer these questions on a separate sheet of paper.  Show your work!!!!!

1.     Colorblindness is a sex-linked, recessive disorder.  What are the probable offspring outcomes from a father who is colorblind and a mother who is homozygous normal vision? Show your work!

2.     Myopia (poor eyesight) is a sex-linked, recessive disorder found in Reebops.  What are the probably offspring outcomes from a father reebop who has normal eyesight and a mother reebop who was myopia.  Show your work with a punnett square!

3.     Duchenne Muscular Dystrophy is caused by a recessive allele located on the X chromosome.

a.     Draw a Punnett square that show how two unaffected people can have a child with muscular dystrophy.  Include the genotypic ratio and phenotypic ratio for the offspring. 

b.     Is the child with muscular dystrophy male or female?

c.     What is the probability that the couple's next child will have muscular dystrophy?

d.     What percentage of the couple's male children will probably have muscular dystrophy?

e.     What percentage of the couple's female children will probably have muscular dystrophy?

4.      Hypophosphatemia, a disorder that causes low phosphate levels in the body and can cause bowed legs, is caused by a dominant allele on the X chromosome.

a.     Using A to represent the allele for hypophosphatemia, draw a punnett square that shows the possible offspring from a woman with genotype X^AX^a and a man with genotype X^AY.

b.     What percentages of the children have hypophosphatemia?

c.     Are males more likely to have the disorder than females? Explain.

d.     Draw a Punnett square that show the possible offspring of a woman with a normal phenotype and a man with hypophosphatemia. Include the genotypic and phenotypic ratios for the offspring.

e.     What percentages of the children have the disorder for this cross?

f.     What percentages of the male offspring have the disorder for this cross? Explain this result.

5.     Color-blindness is a sex-linked trait in humans.  Normal vision (X^B) is dominant over colorblindness.  Achondroplasia (a type of dwarfism) is an autosomal disorder.  Achondroplasia is dominant (A) to average height (a), though if a zygote inherits two dominant alleles (AA) it dies at birth.  

a.     Complete a two-factor Punnett square to predict the offspring for a colorblind, male with achondroplasia (X^bYAa) and a heterozygous normal vision female with achondroplasia (X^BX^bAa).  

b.     What is the probability that they will have a child that is colorblind and Achondroplasiac?  Don't forget to exclude offspring with AA genotypes

6.     What is the pattern of inheritance that is illustrated for questions #1-5?

2/5/13

1. Review H.W.
2. REEBOP Lab- day 1

H.W. More patterns of inheritance practice problems

2/4/13

1. W.U. Pure Gold
2. Review patterns of inheritance
3. Notes: Sex Linked Traits

H.W. Patterns of Inheritance Practice Problems

2/1/13

1. Review H.W.
2. W.U. Heterozy"goats"
2. Notes: 11.3- Other Patterns of Inheritance

H.W. Have a nice weekend!!!